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Recombinant human HBEGF protein, C-His (bs-42477P)  
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產品編號 bs-42477P
英文名稱 Recombinant human HBEGF protein, C-His
中文名稱 重組人肝素結合性表皮生長因子蛋白
別    名 HB EGF; Diphtheria toxin receptor; DT R; DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF_HUMAN; HEGFL; heparin binding EGF like growth factor; Heparin binding epidermal growth factor; Heparin binding epidermal growth factor like growth factor; Heparin-binding EGF-like growth factor; Proheparin binding EGF like growth factor.  
理論分子量 10.9kDa
性    狀 Liquid
濃    度 >0.5mg/ml
緩 沖 液 20mM Tris-HCL (pH=8.0) with 8M Urea
保存條件 Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.
產品介紹 Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a 22kDa O-glycosylated protein that is a potent mitogen and chemoattractant for vascular smooth muscle cells, fibroblasts and epithelial cells but not endothelial cells. The natural protein has an apparent molecular mass of 19-23 kDa and exists in multiple forms as a result of heterogeneous O-glycosylation and/or Nterminal truncation. HB-EGF is synthesized as a membrane-anchored precursor(proHB-EGF) that is proteolytically cleaved to release the soluble mature growth factor. The two forms are active as juxtacrine and paracrine/autocrine growth factors respectively.HB-EGF activates two EGF receptor subtypes, HER1/ErbB1 and HER4 and binds to heparan sulfate proteoglycan.

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